Store only in original packaging, cool & dry place. Do not expose to direct humid air, light, or humid source. Keep away from children & dosage provided under parenteral guidance.
ABOUT LACTOIMMUNE-Q ACTIVES:
N-ACETYL CYSTEINE [NAC]: 35mg
is a form of the amino acid Cysteine present in our body to support immune system function through:
Replenishing glutathione: Glutathione is a potent antioxidant needed for optimal immune system function. (eb™ L-Glutathione)
Breaking down mucus: NAC helps clear mucus seen in respiratory conditions such as bronchitis. Similar to Serrapeptase (eb™ Serrapeptase), NAC is known as a mucolytic – a compound that makes mucus less thick and sticky and easier to clear. NAC has been used for over four decades to clear mucus associated with chronic airway conditions and to help with immunity-related illnesses.
Protecting against bacteria: NAC is capable of disrupting the biofilms of harmful bacteria(s). Researchers propose N-acetylcysteine also works via other mechanisms, such as neutralizing oxygen radicals, pro-inflammatory molecules, and heavy metals. However, these mechanisms require further research.
Support Immunity: NAC is the prodrug form of the amino acid L-cysteine, meaning that it turns into L-cysteine when ingested. In turn, L-cysteine increases body’s levels of glutathione – a potent anti-oxidant. Because glutathione is involved in healthy immune system function and can become depleted due to immunity-related conditions, supplementing N-acetylcysteine is believed to support immunity by keeping glutathione levels optimal.
Why so special for Dietary or Nutritional benefits in Vulnerable & Sick ones: If your glutathione levels are already healthy, then N-acetylcysteine supplementation will not raise them any further. This helps explain why N-acetylcysteine supplementation seems to be most effective in older adults, weak children, vulnerable & sick adolescents, as they are more likely to have low glutathione with higher rates of frequent infections.
Dosage for Immunity:
Adult Clinical (studies) have used: 600 – 2400 mg divided 1-2 times daily
Children (above 10) & Adolescent Dose: 30 – 70 mg, once or twice daily for dietary needs only.
Abundant fluid intake supports the mucolytic effect of acetylcysteine.
2. CITRUS BIOFLAVONOIDS: 50mg
Polyphenolic compounds made from plants and are typically found in certain fruits and vegetables. Some foods, such as chocolate and wine, contain bioflavonoids as well. They are important natural compounds with diverse biologic activities. They are an important part of proper nutrition because they act as potent antioxidants.
constitute an important series of flavonoids. They are derived naturally from citrus fruits, and they have been shown to act synergistically with vitamin C to neutralise free radicals. The major bioflavonoids found in citrus fruits are diosmin, diosmetin, hesperidin, naringin, naringenin, narirutin, neohesperidin, nobiletin, tangeretin, quercetin, rutin, eriodictyol and eriocitrin.
have been shown in studies to be potent antioxidants. Increasing our intake of bioflavonoids helps to prevent free radicals from causing harm in the body. The antioxidant and anti-inflammatory benefits of citrus bioflavonoids have been shown to support metabolic, circulatory, cognitive and joint health. Citrus bioflavonoids support balanced immune cell activity for better immune response, and support for respiratory health.
have a synergistic function with vitamin C for enhanced immune support, and have also been shown to increase the absorption of vitamin C. They provide metabolic support and help to maintain healthy cholesterol levels.
are ideal for applications targeting support for the immune system, respiratory health, cognitive health, vascular integrity, metabolism, cholesterol, joint health and systemic antioxidant support.
eb™LIQ’s Citrus Bioflavonoids are carefully selected to a total bioflavonoid content by HPLC, measuring specific antioxidant activity against the most influential free radicals that are naturally found in the human body: hydroxyl, peroxyl, peroxynitrite, singlet oxygen and superoxide anion. They might also get examined for NF-kB values. NF-kB plays a key role in regulating and balancing the immune response.
sourced from orange, lemon, lime, tangerine and grapefruit provide the broadest bioflavonoid profiles. Each one offers its own unique profile, creating better opportunities for customised formulations.
Standardised bioflavonoid ingredients ensure consistency in every eb™ formulation manufactured batch.
3. BETA-GLUCANS: 200mg
These are naturally occurring polysaccharides. These glucose polymers are constituents of the cell wall of certain pathogenic bacteria and fungi.
The healing and immune-stimulating properties of mushrooms have been known for thousands of years in the Eastern countries. These mushrooms contain biologically active polysaccharides that mostly belong to group of beta-glucans.
These substances increase host immune defence by activating complement system, enhancing macrophages and natural killer cell function.
The induction of cellular responses by beta-glucans is likely to involve specific interaction with several cell surface receptors, as complement receptor 3 (CR3; CD11b/CD18), lactosylceramide, selected scavenger receptors, and dectin-1 (betaGR).
β-Glucans also show anti-carcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens. As immune-stimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, beta-glucan can inhibit tumor growth in promotion stage (few studies).
Anti-angiogenesis can be one of the pathways through which beta-glucans can reduce proliferation.
The following wording reflects the scientific evidence: “Regular consumption of beta-glucans contributes to maintenance of normal blood cholesterol concentrations.” In order to bear the claim, foods should provide at least 3 g/d of beta-glucans from oats, oat bran, barley, barley bran, or mixtures of non-processed beta-glucans.
In November 2011, the EU Commission published its decision in favour of oat beta-glucans with regard to Article 14 of the EC Regulation on the labelling of foodstuffs with nutrition and health claim statements permitting oat beta-glucan to be described as beneficial to health. Following the opinion of the Panel on Dietetic Products, Nutrition and Allergies (NDA) the EFSA and the Regulation (EU) no. 1160/2011 of the Commission, foodstuffs through which 3 g/day of oat beta-glucan are consumed (1 g of oat beta-glucan per portion) are allowed to display the following health claim: “Oat beta-glucan reduces the cholesterol level in the blood. The lowering of the blood cholesterol level can reduce the risk of coronary heart disease.”
Wound healing and immunomodulation: In preliminary research, oat β-glucan is being studied for its potential immunomodulatory effects, anti-tumour properties, and stimulation of collagen deposition, tissue granulation, reepithelization, and macrophage infiltration in the wound healing process.
4. LACTOFERRIN: 100mg
An iron-binding glycoprotein. Lactoferrin is a well conserved, monomeric 80-kDa single polypeptide chain glycoprotein of about 690 amino acid residues.
A cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization.
Immune responses are designed to interact with the environment to protect the host against pathogenic invaders, conferring a state of health through effective elimination of infectious agents (bacteria, viruses, fungi, and parasites) and modulation of systemic responses comprising host immune surveillance.
Recent research has identified Lactoferrin, a member of the transferrin family of iron binding glycoproteins, as a critical component in mediation of immune response, especially for coordinated interactions between innate and adaptive components and associated responses.
Engagement of innate components leads to triggering of signal pathways to promote inflammation, ensuring that invading pathogens remain in check while the specific immune response is either generated or upregulated. Lactoferrin is a key molecule involved in these processes.
The immune system protects the body from potentially harmful environmental stimuli through recognition and responding with multiple immunological reactions. Myeloid cells, including the highly phagocytic, motile poly-morpho-nuclear neutrophils, macrophages and dendritic cells, provide a first line of defense against most pathogens. There is emerging evidence that many mediators originating from the myeloid lineage revive immune homeostasis in most insult-induced metabolic disparity. Thus, the utility of such immune mediators represents a novel approach that depends on immune-potentiation, immunosuppression, or induction of immunological tolerance.
Lactoferrin is one of these mediators that naturally bridge the innate and adaptive immune functions by regulating target cell response, including those involved in oxidative stress and systemic inflammatory responses. It is also recognized as a significant contributor in regulation of antigen presentation and development of productive T helper cell response.
While Lactoferrin is found primarily in mucosal secretions, synthesized by epithelial cells, it is also present in neutrophilic granules. Lactoferrin is considered a first-line defence protein involved in protection against a multitude of microbial infections and prevention of systemic inflammation.
Lactoferrin also exhibits direct effects on pathogens, These include bacteriostatic and bactericidal effects, the former being a result of iron sequestration by Lactoferrin and the latter dealing with Lactoferrin capabilities to bind lipopolysaccharide.
The ability of Lactoferrin to bind large quantities of iron also provides protection against pathogens and their metabolites by enhancing phagocytosis and cell adherence and controlling the release of proinflammatory cytokines.
While suppressing microbial growth, Lactoferrin also exerts direct first-line defence activity through its significant impact on the development of adaptive immune responses. Sequestration of iron by Lactoferrin reduces insult-induced oxidative stress, thus altering the magnitude and specific production of cytokines.
Lactoferrin has a profound modulatory action on the adaptive immune system by promoting the maturation of T-cell precursors into competent helper cells and by the differentiation of immature B-cells into efficient antigen presenting cells. In addition, Lactoferrin augments the delayed type hypersensitivity (DTH) response to antigens, leading to a strong induction of cell-mediated immunity in mice.
Lactoferrin is a key element to combat excessive inflammation and direct host immune function to protect against overaggressive microbial insults. Found in exocrine secretions, Lactoferrin serves as a natural regulator of host defence. It is one of the first factors released by neutrophils upon encounter with pathogens and contributes to innate activation by directing development of adaptive responses. In combination with its historical role in limiting microbial proliferation and functioning as a direct microbicidal agent, Lactoferrin plays a central role in host immunity. Lactoferrin has the ability to modulate cytokine production from monocytes, as well as from lymphocytes, during activation from foreign stimuli or mitogens. In addition, along with co-stimulatory mediators, Lactoferrin can modulate chemokine recognition and lymphocyte migratory potential. This, coupled with the ability to affect production and activity of reactive oxygen species, allows Lactoferrin to serve as a unique regulator to a wide array of responses, including those involved in septic shock (e.g. systemic inflammatory response syndrome), inflammation, and subsequent development of disease related pathologies.
5. QUERCETIN: 150mg
Quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability.
Quercetin, a flavonoid found in fruits and vegetables, has unique biological properties that may improve mental/physical performance and reduce infection risk. These properties form the basis for potential benefits to overall health and disease resistance, including anti-carcinogenic, anti-inflammatory, antiviral, antioxidant, and psychostimulant activities, as well as the ability to inhibit lipid peroxidation, platelet aggregation and capillary permeability, and to stimulate mitochondrial biogenesis. Therefore, there is a pressing need for well-designed clinical trials to evaluate this novel dietary supplement further.
Quercetin is categorized as a flavonol, one of the six subclasses of flavonoid compounds. The name has been used since 1857, and is derived from quercetum (oak forest), after Quercus. It is a naturally occurring polar auxin transport inhibitor.
The International Union of Pure and Applied Chemistry (IUPAC) nomenclature for quercetin is 3, 3′, 4′, 5, 7-pentahydroxyflvanone. This means that quercetin has an OH group attached at positions 3, 5, 7, 3′, and 4′.
Quercetin (C15H10O7) is an ‘A-Glycone’, lacking an attached sugar. It is a brilliant citron yellow needle crystal and entirely insoluble in cold water, poorly soluble in hot water, but quite soluble in alcohol and lipids. The attached glycosyl group can change the solubility, absorption, and in vivo effects. As a general rule of thumb, the presence of a glycosyl group (quercetin glycoside)(eb™LactoImmuneQ : eb™LIQ) results in increased water solubility compared to quercetin aglycone.
A quercetin-glycoside (eb™LIQ) is unique by the attached glycosyl group. Generally, the term quercetin should be used to describe the aglycone only; however, the name is occasionally used to refer to quercetin-type molecules, including its glycosides in research and the supplement industry.
6. HOLY BASIL: 200mg
Holy Basil Supplementation outcome measurements:
Healthy blood glucose levels
Better lipid profile
Maintained blood pressure
Strong immune response
Improving neurocognitive changes
Helps in fatigue
Healthy serum uric acid levels
Helps in diabetes’ secondary symptoms
Enhanced immune response
Increased immune response with increased Natural Killer (NK) and T-helper cells in healthy adult
Neurocognitive Effect: improvements in mood and/or cognitive function regardless of age, gender, formulation, dose, or quality of the study.
7. VITAMIN C (L-Ascorbic Acid): 200mg
Contribute to normal collagen formation essential for normal function of bones, cartilage, blood vessels, skin, gums and teeth.
Contribute to normal energy-yielding metabolism and functioning of the nervous system.
Contribute to normal function of the immune system and reduction of tiredness and fatigue.
Contribute to the protection of cells from oxidative stress.
Contribute to normal absorption/utilization of calcium and phosphorus.
Contribute to normal iron absorption and regeneration of the reduced form of Vitamin E.
8. FOLATE (FOLIC ACID): 400µg
Folic acid is known as folate a form of the B group vitamins.
Very important for the formation of red blood cells
Folate is required during the period of infancy or pregnancy for the rapid cell division.
Important nutrient to help protect against anaemia at all age.
Folic Acid tablets may be of benefit to;
Women who are trying to conceive or are already in their first trimester
Women who suffer from heart problems.
Those who have low red blood cell count.
9. VITAMIN B6 (Pyridoxine HCl): 1.5mg
Beneficial for mental and physical health
May help to convert carbohydrates to glucose and thus provides energy.
May help in fat and protein metabolism
Keep digestive tract and nervous system healthy
May help maintain skin, eyes and liver healthy
May support heart health
May help with symptoms of PMS and nausea
Enhance the activity of immune system
Helps to combat stress and fatigue
Vitamin B6 may be of benefit to;
All including children, adults and seniors.
Women undergoing hormonal changes.
People with heart related problems.
Those suffering from mental stress.
Seniors with poor bone and joint health.
Those who suffer from nervous tension and muscle co-ordination problems.
10. COPPER (Cu):1mg
Copper (Cu) is an essential trace mineral in the human body. It is required for growth, bone strength, immune function, as well as heart function, and brain development.
Copper contributes towards a normal function of the nervous system and the energy metabolism and maintenance of connective tissue.
Copper increases the production of collagen (which provides strength and structure) and elastin (which provides skin elasticity and resilience)
Copper plays an important role in bone formation. It is a cofactor for enzyme lysyl oxidase required for the formation of strong bones.
Maintains Heart Health
Copper plays a part in many of your body’s organs and systems. It helps you:
Make red blood cells
Keep nerve cells healthy
Support your immune system
Form collagen, a protein that helps make up your bones and tissues
Protect cells from damage
Absorb iron into your body
Turn sugar into energy
11. SELENIUM (Se): 20 µg
Selenium (Se) is a trace element found in the soil. Selenium is only required in very small amounts, but plays a number of vital roles in our body.
Selenium activates one of the most important antioxidant enzymes in the body protecting tissue cells from oxidative damage caused by free radicals.
It is also essential for supporting the functionality of the immune system.
Helps support all forms of skin irritation through oxidation.
Helps the body process proteins to improve hair growth.
Contains a number of powerful antioxidants to help reduce inflammation associated with joint pain.
Selenium is an essential trace mineral that is thought can help to defend the body’s cells against oxidative stress caused by ‘free-radicals’, which is thought to be a leading cause of disease and premature ageing.
Selenium has also been shown to support a healthy immune system, fertility and thyroid function.
Over farming and modern food processing techniques mean that there are now significantly lower levels of selenium in the foods we eat. A survey carried out in 2011 found that 90% of people living in the UK consume less than the EU recommended intake of selenium, and up to 40% don’t even get a quarter.
Electrolytes are a type of mineral found naturally in the body. They include sodium, magnesium, chloride, calcium, and potassium, among others. These minerals are important for a wide range of bodily functions and are essential for the proper functioning of the cardiovascular, endocrine, and nervous systems.
Each electrolyte has a specific purpose in the body that we can’t live without. This includes:
Sodium: helps to manage the amount of water in the body. It also helps support healthy muscle and nerve function. Plus, sodium regulates our fluid retention to help prevent dehydration.
Potassium: We can get potassium from fresh fruit and veggies. It’s essential for the functioning of our digestive system and a handful of major organs.
Calcium: This mineral is essential for strong, healthy bones. As an electrolyte, it’s also important for regulating muscle contractions and supporting our heart health.
Magnesium helps boost our immune and cardiovascular systems. It also plays a supporting role in our nerve and muscle function.
Chloride: This mineral is found in table salt, seaweed, and rye, among other foods. Our bodies use chloride to help maintain our pH and fluid levels.